Saturday, July 29, 2006

Scientists Spot Chronic Pain 'On/Off' Switch

FRIDAY, July 28 (HealthDay News) -- U.S. researchers say they've identified a protein in nerve cells that acts as a kind of gatekeeper for .
This enzyme, called protein kinase G (PKG), is turned on and activated in response to injury or inflammation. Once activated, PKG triggers other processes that generate pain messages that are sent to the brain. As long as PKG is switched on, pain persists. Turning PKG off relieves pain.
"We're very optimistic that this discovery and our continued research will ultimately lead to a novel approach to pain relief for the millions suffering from chronic pain," researcher Richard Ambron, professor of cell biology at Columbia University Medical Center in New York City, said in a prepared statement.
The study was published online in the journal Neuroscience and was expected to be in the August print issue.
Ambron and his colleague Ying-Ju Sung, an assistant professor of cell biology, have applied for a patent for the pathway that turns on PKG, as well as several molecules that inhibit it. They hope to develop a new class of drugs that target PKG in order to treat chronic pain.
More information
The American Academy of Family Physicians has more about chronic pain
Last reviewed: 07/28/2006 Last updated: 07/28/2006

Patient's Sexuality May Have Impact on Care

FRIDAY, July 28 (HealthDay News) -- Doctors, nurses and other health care professionals react more positively to men who reveal they're gay than to women who disclose they're lesbians, concludes a New Zealand study in the Journal of Advanced Nursing.

The Massey University survey of 2,269 gay, lesbian and bisexual people also found that those over age 40 were more likely to report positive experiences when they revealed their sexuality to their primary health care providers.

"It's important that health care providers are aware of people's sexuality as non-disclosure has been shown to have a negative impact on their health," researcher Dr. Stephen Neville said in a prepared statement.

"For example, people who are lesbian, gay and bisexual are more likely to face an increased risk of suicide, depression and other mental health problems," Neville said.

Among the study's findings:
83 percent of women and 66 percent of men said that their health care provider assumed they were heterosexual. This assumption was more likely if the patient was under age 40.
Women were more likely to disclose their sexuality than men (72 percent vs. 65 percent), as were people over age 40.

86 percent of men and 78 percent of women said their health care provider was "completely comfortable" with their disclosure; 11 percent of women and six percent of men said their health care provider was "somewhat comfortable;" and 11 percent of women and eight percent of men said their health care provider ignored the disclosure.

43 percent of men and 28 percent of women said they felt their health care provider's attitude to their disclosure had a positive effect on their care, compared to 10 percent of men and five percent of women who felt it had a negative effect.

"Previous studies have shown that people are more likely to seek health care and adhere to treatment regimes if they know that health care providers will be comfortable with their sexuality and not automatically assume they are heterosexual," Neville said.

More information
The Gay and Lesbian Medical Association has more about gay and lesbian health issues.

Health Tip: Recognize Anaphylactic Shock

(HealthDay News) -- Anaphylactic shock occurs when a person has ingested or come in contact with a substance to which they are severely allergic. The reaction can be life-threatening.
The Food Allergy and Anaphylaxis Network says people with food allergies -- especially shellfish, peanuts and other nuts -- are at especially high risk of anaphylactic shock, particularly if they have had a previous reaction.

Symptoms typically include a feeling of itchiness or tingling; metallic taste in the mouth; hives; difficulty breathing; swollen mouth or throat; vomiting; diarrhea; or unconsciousness.
Symptoms should be recognized quickly. A shot of epinephrine is typically administered to counter the reaction.

Last reviewed: 07/28/2006 Last updated: 07/28/2006

Sunday, July 23, 2006

Clinical Trials Update: May 15, 2006

(HealthDayNews) -- Here are the latest clinical trials, courtesy of CenterWatch:
Ulcerative Colitis
This study is being conducted in the U.S. and Europe to evaluate the safety and efficacy of visilizumab for the treatment of severe ulcerative colitis (UC). Volunteers at least 18 who have been diagnosed with UC by colonoscopy or barium enema within 36 months and have an active disease despite ongoing treatment with steroids may qualify. Volunteers will participate in intensive weekly-to-monthly evaluations for one year.
Research sites are located throughout the world.
More Information
Please see http://www.centerwatch.com/patient/studies/cat152.html.
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Vaginal Atrophy
This clinical research study will evaluate an investigational medication to treat symptoms of menopause. Women 40 to 65 who have not had a hysterectomy, a period for at least six months, and have at least one moderate-to-severe vaginal symptom such as dryness, irritation, itching, or pain with sexual activity may be eligible.
The research site is in Chaska, Minn.
More Information
Please see http://www.centerwatch.com/patient/studies/cat639.html.
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Leukemia
This study will evaluate the effectiveness of cloretazine in elderly patients with poor risk de novo AML. Volunteers must be at least 60, have had no prior chemotherapy with or without radiation, and no history of MDS, myeloproliferative disease or favorable cytogenetics. In addition, patients must meet at least one of the following criteria: unfavorable cytogenetics, ECOG 2, cardiac / pulmonary / hepatic/ organ dysfunction, or be at least 70 years or older.
The research site is in Indianapolis, Ind.
More Information
Please see http://www.centerwatchcom/patient/studies/cat92.html.
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Copyright 2006 CenterWatch. All rights reserved.
Last reviewed: 05/15/2006 Last updated: 05/15/2006

Clinical Trials Update: May 1, 2006

HealthDay News) -- Here are the latest clinical trials, courtesy of CenterWatch:
McCune-Albright Syndrome
This study will evaluate the safety and effectiveness of a drug called Faslodex (fulvestrant) to treat early puberty in girls with McCune-Albright Syndrome (MAS). Females younger than 11 diagnosed with progressive precocious puberty before age 8 who have not received any prior treatment for early puberty may qualify.
Research sites are located throughout the United States.
More information
Please see http://www.centerwatch.com/patient/studies/cat260.html.
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Ulcerative Colitis
The RESTORE study is being conducted in the United States and Europe to evaluate the safety and effectiveness of the drug visilizumab to treat severe ulcerative colitis. Volunteers at least 18 who have an active disease despite ongoing treatment with steroids may qualify. Eligible patients will participate in 90 days of intensive weekly-to-monthly evaluations and every third month follow-up for one year.
Research sites are located across the United States.
More information
Please see http://www.centerwatch.com/patient/studies/cat152.html.
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Diabetic Foot Ulcers
HOPE Research Institute is enrolling diabetic adults in a research study of an investigational treatment for diabetic foot wounds. Candidates 18-80 who have diabetes and at least one foot wound may be eligible. Study participants will receive study supervision by a board-certified podiatrist, study-related tests and exams, study medication, as well as compensation for time and travel.
The research site is in Phoenix, Ariz.
More information
Please see http://www.centerwatch.com/patient/studies/cat229.html.
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Copyright 2006 CenterWatch. All rights reserved.
Last reviewed: 05/01/2006 Last updated: 05/01/2006

Clinical Trials Update: Nov. 3, 2005

(HealthDay News) -- Here are the latest clinical trials, courtesy of CenterWatch:
Colon Cancer Screening
This study looks at the effect of folate supplementation and depletion on the blood cells and the colorectal cells.
To examine the effect of these changes, blood samples and colorectal biopsy samples are collected. Men or post-menopausal women 40-to-72 years old that have a personal history of colorectal denomatous polyps and/or have a family history of colorectal cancer or polyps will be included.
The research site is in New York City.
More Information
Please see http://www.centerwatch.com/patient/studies/cat507.html.
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Kidney Cancer
The purpose of this study is to determine the safety and effectiveness of an experimental therapy -- using the antibody cG250 -- in preventing the return of the kidney tumor.
The research site is in Los Angeles.
More Information
Please see http://www.centerwatch.com/patient/studies/cat33.html.
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Ulcerative Colitis
This six month study requires patients with a diagnosis of mild to moderate ulcerative colitis in remission.
If qualified, patients receive study medication, exams and lab work at no cost; time and travel may also be compensated.
Candidates should be 18 years or older, have mild to moderate ulcerative colitis in remission and have a history of at least one flare (with symptoms) within the past year.
The research site is in Ormond Beach, Fla.

More Information
Please see http://www.centerwatch.com/patient/studies/cat152.html.
-----
Copyright 2005 CenterWatch. All rights reserved.
Last reviewed: 11/03/2005 Last updated: 11/03/2005

Clinical Trials Update: April 17, 2006

Published: 04/17/06
(HealthDay News) -- Here are the latest clinical trials, courtesy of CenterWatch:
Urinary Incontinence
Pivotal Research Centers is conducting a research study with an investigational medication for overactive bladders in women.
Eligible candidates should be women ages 18-65 who urinate more than eight times in a 24-hour period.
Participants will receive at no cost a study-related drug and physical and will be compensated for their time and travel.
The research site is in Peoria, Ariz.
More information
Please see http://www.centerwatch.com/patient/studies/cat195.html.
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Ulcerative Colitis
This study is designed to establish the safety and tolerability of a single dose of MDX-1100 in patients with ulcerative colitis.
Successful canndidates should be 18 years or older with active ulcerative colitis and a DAI no less than 4 and no greater than 9. They should not have a history of colectomy, partial colectomy, current ostomy, or pouchitis. Other criteria also apply.
The research site is in Los Angeles.
More information
Please see http://www.centerwatch.com/patient/studies/cat152.html.
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Erectile Dysfunction
This is a research study of an approved oral medication for Erectile dysfunction (ED).
Gay men who are experiencing ED may qualify, if they are in a stable relationship with one male partner.
Study-related care and medication will be provided at no charge to qualified volunteers.
The research site is in Houston, Tex.
More information
Please see http://www.centerwatch.com/patient/studies/cat371.html.
-----
Copyright 2006 CenterWatch.
All rights reserved.

Friday, July 21, 2006

Exercise Works Wonders in Middle Age

WEDNESDAY, July 19 (HealthDay News) -- Even if you only start to exercise after age 40, you can still greatly reduce your risk of heart disease, suggests a study in the current issue of Heart.
German researchers interviewed 312 people, aged 40 to 68, with coronary artery disease and 479 healthy people in the same age group. Participants were asked about their level of physical activity in early adulthood (ages 20 to 39) and in late adulthood (after age 40).
According to the University of Heidelberg team, about half of the people with heart disease and 70 percent of the healthy volunteers said they'd been moderately or very physically active during early and late adulthood.
People who'd been active all their lives were about 60 percent less likely to have coronary heart disease. The study also found that people who became very physically active after age 40 were about 55 percent less likely to be diagnosed with heart disease than people who'd been inactive their entire lives.
While people who've exercised all their lives are more likely to enjoy better health, these findings suggest that beginning to exercise later in life still offers many benefits and can reduce the risk of heart disease, the study authors concluded.
More information
The American Academy of Family Physicians has more about exercise.
Last reviewed: 07/19/2006 Last updated: 07/19/2006

Health Tip: Prevent Osteoporosis

(HealthDay News) – Osteoporosis is a condition in which bones become brittle, fragile and break easily. Fractures from osteoporosis typically occur in the hip, spine or wrist. The condition affects mostly women over age 50, but can also affect men.

There are rarely obvious symptoms associated with osteoporosis, but tests can be done to check for bone mass and density. Osteoporosis is usually diagnosed when a weakened bone breaks from a fall or injury.

Prevention should begin early -- even as young as childhood, the National Osteoporosis Foundation says. Diets rich in calcium and vitamin D can help strengthen bones. Getting plenty of exercise and avoiding smoking and alcohol also are important in preserving bone health.

Last reviewed: 05/16/2006 Last updated: 05/16/2006

Cornea Research Brings Clear-Eyed View on Cancer

THURSDAY, July 20 (HealthDay News) -- A new study pinpoints the key role of a specific growth factor in keeping eyes healthy. The finding might even aid cancer research, researchers say.
U.S. researchers say large amounts of the protein VEGFR-3 (vascular endothelial growth factor receptor-3) on the top epithelial layer of the cornea keeps the cornea transparent and free of blood vessels and, thus, makes vision possible.

The cornea is the thin, clear tissue that covers the front of the eye. It's one of the few tissues that actively keeps itself free of blood vessels. Until now, researchers did not know exactly how the cornea managed to do this.

VEGFR-3 inhibits blood vessel growth in the cornea by binding or neutralizing growth factors that would normally stimulate blood vessel growth, said scientists at the Schepens Eye Research Institute and Massachusetts Eye and Ear Infirmary.

Their finding was published in this week's online issue of the Proceedings of the National Academy of Sciences, and is expected to be published in the July 25 print issue.
The study answers a scientific mystery and may also eventually help researchers find ways to prevent and cure blinding eye diseases and also illnesses such as cancer, where blood vessels grow abnormally and uncontrollably.

"Drugs designed to manipulate the levels of this protein could heal corneas that have undergone severe trauma or help shrink tumors fed by rapidly growing abnormal blood vessels. In fact, the next step in our work is exactly this," study senior author Dr. Reza Dana, senior scientist at Schepens and head of the Cornea Institute at the Massachusetts Eye and Ear Infirmary, said in a prepared statement.

More information
The U.S. National Eye Institute has more about the cornea and corneal disease.
Last reviewed: 07/20/2006 Last updated: 07/20/2006

Distress: The Sixth Vital Sign?

FRIDAY, June 23 (HealthDay News) -- In assessing a patient's condition, doctors traditionally check five vital signs -- pulse, breathing, temperature, blood pressure and pain. But one cancer physician wants to add another vital sign to the list -- distress.

A patient's mental well-being is an essential part of overall health and should be monitored -- even during routine medical examinations, said Dr. Jimmie C. Holland, who holds the Wayne E. Chapman Chair in Psychiatric Oncology at Memorial Sloan-Kettering Cancer Center, in New York City.

"Can distress become the sixth vital sign?" Holland asked. "I ask this, because we must find a way to incorporate psychological care into total care," she said.

"No patient with distress should be unrecognized or untreated in quality cancer care.
I don't think you can have quality cancer care that does not integrate this psychological side. There should be a minimum standard for psychosocial care," she added.

Holland explained her proposal Thursday at a cancer briefing sponsored by the American Medical Association, in New York City.

One big problem is that doctors often don't consider the psychological component of total health, and patients are reluctant to bring it up, because they don't want to bother the doctor, Holland said. Part of the barrier comes from the doctor -- "Hey, I'm doing science not touchy-feely stuff. And patients are going to tell me when they're upset," she said, paraphrasing a typical physician.
As for patients, Holland believes many are embarrassed discussing psychological issues. "The doctor will think I'm a wimp," Holland said, again paraphrasing.

But studies have found that as many as 45 percent of cancer patients have significant mental distress, Holland said. "Those most at risk are those with the most serious tumors, young patients, patients with low income and those with less social support," she said.

To help get physicians to evaluate a patient's mental condition, Holland and colleagues at the National Comprehensive Cancer Network have developed a questionnaire for patients to complete at routine doctor visits. The questionnaire alerts doctors to those patients who may need to be referred for counseling.

Along with the questionnaire, Holland and her colleagues have developed practice guidelines for dealing with patient distress. Holland created a scale that rates a patient's distress on a 1-to-10 scale, what she calls a "distress thermometer."

"Patients who score 4 or greater, that's the trigger that doctors should note," she said.
Based on this scale, patients can be referred to psychiatrists, psychologists, social workers or pastoral counseling. "Distress should be monitored continually," Holland said.

Holland believes that adding distress to regular evaluations leads to more open communication and encourages treatment; hence, fewer patients will become overly anxious, and there will be fewer patient visits because of worry.

"We can decrease distress and improve the quality of patient's lives," Holland said. "We don't change their survival, but it is about changing what happens to them," she said.
One cancer expert agreed that instituting a method to monitor patient distress is essential to good care.
"Whenever you go into a hospital, the nurses and physicians are very tuned into the pain scale," said Dr. Carolyn D. Runowicz, president of the American Cancer Society and director of the Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center.
"I would hope that for cancer and all patients, that something like the distress thermometer is incorporated," Runowicz said. "It may take regulation to get it incorporated, but whatever it takes, we will end up with a better result," she said.
More information
The National Comprehensive Cancer Network can tell you more about distress and cancer.
Last reviewed: 06/23/2006 Last updated: 06/23/2006

Sunday, July 16, 2006

Some ayurvedic products have toxic amounts of heavy metals

Doctors in the USA are becoming alarmed at the toxic amounts of heavy metals found in some ayurvedic products. Ayurvedic medicine is ancient Hindu science of health and medicine. Ayurvedic products generally means herbal products. An analysis of a sample of Ayurvedic herbal medicine products found that 20 percent contained metals such as lead, mercury and arsenic at levels that could be toxic if taken as directed, according to a study in the December 15 issue of JAMA.

According to background information in the article, approximately 80 percent of India's one billion population uses Ayurveda, a medical system that originated in India more than 2000 years ago and greatly relies on herbal medicine products (HMPs).

Ayurveda's popularity in Western countries has increased. Because Ayurvedic HMPs are marketed as dietary supplements, they are regulated under the Dietary Supplement Health and Education Act (DSHEA), which does not require proof of safety or efficacy prior to marketing. Herbs, minerals and metals are used in Ayurvedic HMPs. Recent reports of serious lead poisoning associated with taking Ayurvedic HMPs were the impetus for the current study. Robert B. Saper, M.D., M.P.H., formerly of Harvard Medical School, Boston, (currently with the Boston University School of Medicine) and colleagues examined Ayurvedic HMPs manufactured in South Asia and sold in Boston-area stores in order to examine their heavy metal content. From April to October 2003, the researchers purchased 70 different Ayurvedic HMPs at stores within 20 miles of Boston City Hall. Concentrations of lead, mercury and arsenic were measured in the samples. The potential amount of daily metal ingestion, estimated by using manufacturers' dosage recommendations, was compared to U.S. Pharmacopeia and U.S. Environmental Protection Agency regulatory standards.

The researchers found that 14 (20 percent) of the 70 HMPs contained lead, mercury and/or arsenic, and that if taken as recommended by the manufacturer, each of these could result in heavy metal intake above the published regulatory standards. Lead was found in 13 HMPs; mercury in six HMPs; and arsenic in six HMPs. Half of the HMPs containing potentially toxic heavy metals were recommended for children. The 14 HMPs containing heavy metals were manufactured by 11 different companies. Of the 30 stores visited, 24 sold at least one heavy metal-containing HMP.

"… the presence of heavy metals in Ayurvedic HMPs and the numerous reports of associated toxicity may have important public health, clinical, and policy implications in the United States and abroad. Although the prevalence of heavy metal-containing Ayurvedic HMP use is unknown, the number of individuals at potential risk is substantial," the authors write.

"Public health and community organizations should consider issuing advisories to current or previous Ayurvedic HMP users, encouraging them to consult their physicians about heavy metal screening."

"Our findings support calls for reform of DSHEA that would require mandatory testing of all imported dietary supplements for toxic heavy metals," they conclude. (JAMA. 2004; 292: 2868-2873. Available post-embargo at http://www.jama.com)
Editor's Note: For funding and financial disclosure information, please see the JAMA article.
Contact: Gina DiGravio617-638-8491
JAMA and Archives Journals Website

What are the major types of complementary and alternative medicine?

NCCAM classifies Complementary and Alternative Medicine (CAM) therapies into five categories, or domains:

1. Alternative Medical Systems Alternative medical systems are built upon complete systems of theory and practice. Often, these systems have evolved apart from and earlier than the conventional medical approach used in the United States. Examples of alternative medical systems that have developed in Western cultures include homeopathic medicine and naturopathic medicine. Examples of systems that have developed in non-Western cultures include traditional Chinese medicine and Ayurveda.

2. Mind-Body Interventions Mind-body medicine uses a variety of techniques designed to enhance the mind's capacity to affect bodily function and symptoms. Some techniques that were considered CAM in the past have become mainstream (for example, patient support groups and cognitive-behavioral therapy). Other mind-body techniques are still considered CAM, including meditation, prayer, mental healing, and therapies that use creative outlets such as art, music, or dance.

3. Biologically Based Therapies Biologically based therapies in CAM use substances found in nature, such as herbs, foods, and vitamins. Some examples include dietary supplements,3 herbal products, and the use of other so-called natural but as yet scientifically unproven therapies (for example, using shark cartilage to treat cancer).

4. Manipulative and Body-Based Methods Manipulative and body-based methods in CAM are based on manipulation and/or movement of one or more parts of the body. Some examples include chiropractic or osteopathic manipulation, and massage.

5. Energy Therapies Energy therapies involve the use of energy fields. They are of two types: -- Biofield therapies are intended to affect energy fields that purportedly surround and penetrate the human body. The existence of such fields has not yet been scientifically proven. Some forms of energy therapy manipulate biofields by applying pressure and/or manipulating the body by placing the hands in, or through, these fields. Examples include qi gong, Reiki, and Therapeutic Touch. -- Bioelectromagnetic-based therapies involve the unconventional use of electromagnetic fields, such as pulsed fields, magnetic fields, or alternating-current or direct-current fields.

NCCAM, National Institutes of Health
Bethesda, Maryland 20892 USA
E-mail: info@nccam.nih.gov

Thursday, July 13, 2006

A Cancer Treatment in the Spice Cabinet?

A growing body of laboratory research suggests the spice turmeric has potent anticancer activity -- and researchers have launched a slew of human trials to find out just how powerful it may be.
"I think the promise is enormous," said Bharat Aggarwal, PhD, chief of the cytokine research laboratory in the department of experimental therapeutics at the University of Texas MD Anderson Cancer Center. Aggarwal has conducted numerous lab and animal studies of turmeric and its primary component, curcumin, and recently gave a lecture on the topic at the annual conference of the Society for Integrative Oncology.

Turmeric is a yellow powder made from the roots of a plant in the ginger family. It is the main ingredient in curry powder and is widely used in Indian and Southeast Asian cooking.
"Turmeric and curcumin are anti-inflammatory," Aggarwal said. "That has been described in traditional medicine like Ayurveda for thousands of years."

Lab and Animal Studies Show Effect on Many Cancers
The early lab research Aggarwal and others have done focuses on curcumin, the most active compound in turmeric. The studies show that curcumin can indeed slow inflammation. It also appears to slow the spread of cancer (metastasis), slow down the growth of new tumor blood vessels (angiogenesis), and cause cancer cells to die the way normal cells do (apoptosis).

What's more, these effects don't appear to be limited to just one type of cancer. Curcumin has shown effects in lab studies against metastatic melanoma, mantle cell lymphoma, and other cancers. Most recently, Aggarwal published a study in the journal Clinical Cancer Research showing that eating curcumin could keep breast cancer from spreading to the lungs at least in mice. In addition, it appeared to enhance the positive effects of the chemotherapy drug paclitaxel and lessen the severity of its side effects.

However, not all research on curcumin has had such positive results. At least one laboratory study suggests curcumin may inhibit the action of other chemotherapy drugs, including camptothecin, mechlorethamine, doxorubicin, and cyclophosphamide. That's why it's so important to conduct well-designed studies in people of how curcumin affects different types of cancer.

At MD Anderson alone, Aggarwal said, doctors are testing curcumin in multiple myeloma and advanced pancreatic cancer. The institution is also seeking funding for a study of curcumin in women with breast cancer, he said. Studies from other institutions, both in the US and overseas, are looking at curcumin as a potential treatment for myelodysplastic syndromes, and for preventing colorectal cancer in individuals with familial adenomatous polyposis or with sporadic polyps.

Curcumin is also being studied as a treatment for Alzheimer's disease and psoriasis.
Citation: "Curcumin Suppresses the Paclitaxel-Induced Nuclear Factor-ĂŞB Pathway in Breast Cancer Cells and Inhibits Lung Metastasis of Human Breast Cancer in Nude Mice." Published in the Oct. 15, 2005, issue of Clinical Cancer Research (Vol. 11, No. 20: 7490-7498). First author: Bharat B. Aggarwal, University of Texas MD Anderson Cancer Center.

American Cancer Society
All American Cancer Society News

Gandhi's Cure for Alzheimers Disease

"Feelings are not supposed to be logical. Dangerous is the man who has rationalized his emotions."-David BorensteinI had the chance to spend last weekend with my 88-year-old grandma and I feel so grateful that she is mentally sharp.

Unfortunately, so many elderly are not as lucky. The National Institute on Aging estimates that some 4.5 million Americans suffer from Alzheimers. What can one do to effectively treat and even prevent Alzheimer's?

I remember a 2005 article that discussed amazing results with art therapy on Alzheimer's patients. A patient who had little memory or awareness, when exposed to paintings, suddenly would become lucid, articulate, and quite interpretive. Said the article, "One avenue of thinking about both music and art...is that it engages parts of the brain that remain intact long after the onset of dementia." Most of our lives, we strive for meaning, ration, and understanding which ultimately batters and weakens a certain part of the brain.

As Joseph Campbell said, "Life is not about the meaning, it's about the feeling." As we are learning from the Alzheimer patients, time spent immersed in creative freedom and FREE from rational knowledge is like a deep tissue massage for an exhausted brain. We can transcend the gradual withering of mind by taking time every single day, if not just for a moment, to set the mind free. A glass of wine, a long walk, your favorite song, a delicious meal. As Gandhi said, "Culture of the mind must be subservient to the heart."Here are some tips to free the mind and massage the creative brain.

Go to a baseball game.
Even if you are not a sports fan, baseball is one of the only things in our culture that is not governed by a clock. There’s something very liberating about escaping time and just relaxing in the summer sun."A hot dog at the ballgame beats roast beef at the Ritz." ~ Humphrey Bogar

Pick up some crayons and let loose.One should hope for their mind to be as free as a 5 year old child. Next time you are at a restaurant where they have crayons for kids to scribble on paper placemats, ask if they have any “adult crayons?”“When I grow up I want to be a little boy.” ~ Joseph Heller

Don’t be too cool for school.Do something ridiculous just for fun. Taper your jeans like you did in the 80’s. Wear giant, round, upside down sunglasses you steal from your grandma. Go dressed to a baseball game in full uniform with your mitt just like when you were a kid.“I don't want to get to the end of my life and find that I lived just the length of it. I want to have lived the width of it as well." ~ Diane Ackerman

Posted by David Romanelli


Sunday, July 09, 2006

You & Your Dark Room

Depression is just like a dark pit, which swallows individuals up and then it is going to put you in a situation where you are left alone. The worst ever situation is that when you are closing yourself out and not letting the light seep through you and you are going down and down and down.

Have you ever thought that your dark room is exactly the same situation of what you are on the inside, dark, helpless, hopeless. Tell me honestly, is this the same situation that you want to be in and believe me I can answer that question for you, and the answer is yes.

Now you need to tell me one thing, is this answer given by you or the state that is ruling you or the feelings that have taken over you? I think this will make you think a little because as far as I know and I believe, this is not you but the state that is answering for you.

I want to ask you another question, for how long do you think you will be able to live in such a situation, don’t you think that how this feeling of yours is affecting you and your loved ones. I believe you do and you feel helpless that you can’t help yourself and thus you just prefer the way you are.

If you are reading this article, I would ask you to not give up on you as a friend, you are the center point of the lives of so many people and those people are just different planets revolving around you. If you think you have no one and you are all alone then again you are getting these messages from your state of mind and not yourself, you have you and you need to understand the strength and value of yourself.

Tell me one thing, if you find someone who is going through the same feelings as you, what are you going to do, aren’t you going to help that person to get out of these feelings, I believe you do, then know how important you are, as you can be a light in the lives of those people who are in their dark rooms inside themselves, alone, all alone.

If you have no one, you have you, and you are the light in the lives of so many people, only if you can understand the strength of that. You need to be alive to help the people live. You are lucky that you have seen such state because you can now understand as to how this state jolts a human being and turns their life upside down and now knowing all this you can fill the lives of others with happiness and love.

I hope I have not offended you at any place because I never meant to, just wanted you to know as to how special and important you are.

by depressiondoctor on April 12th, 2006

What To Do When You Know You Are Suffering From Depression

When you have determined the fact that you are going through the signs and symptoms of depression, you need to know as to what is the next best thing to do. Because if you let those feelings go unnoticed, they are just going to grow and grow and will be taking all over you.

The best thing to do when you have determined that you are going through depression is that you must share your feelings with the ones who you trust. Those can be your parents, anyone in the siblings who you are close with, your friends, any one with whom you will be feeling comfortable to share your feelings with.

The most important thing to know is that you must talk and not isolate yourself, because if you are going to isolate yourself, you are going to try to fight it alone, and believe me it is not easy to fight the feelings of depression alone. You need to talk with someone because you will feel the weight being lifted off of your chest and you will get the smooth feeling inside you.

Even if you get that smooth feeling inside you for a few moments, it is going to be amazing because it is then that you would be starting to open yourself more and not let the bad feelings grow inside you and let them out. What you need is a vent out of the feelings, so that you are able to feel yourself again.

Do not get me wrong, but you will see that when you will start to open up, you will feel much much better than you had been and once you have crossed that barrier of not sharing to sharing, you must not go back in your shell and keep sharing things that grow inside of you, because this is going to save you come out of the feelings you are in and in a matter of days you will be in the moment of clarity, which will pull you out of what you are in now.

by depressiondoctor on April 11th, 2006

What Is Depression ?

People normally think that depression is something that is not a serious issue and they will get over with it in some time, but they are wrong. I would rather say that they are dead wrong. Have you ever seen a tree that is being eaten by termites? The termites just eat out the entire tree bit by bit and if you consider yourself that tree, then consider depression as a termite.

Depression is an alarming situation and is being caused by the change in the levels of the chemicals in the brain that control depression. If these levels go down then the individual suffers from the feeling of depression.


The feeling of depression is something that the individual just tends to get into without knowing as to whether they are falling in that pit unless that condition totally engulfs them. Some people think that they can fight it all along, but this is something of a much higher magnitude than they can ever think.


You must know that depression is a state that is going to move your from the axis of your original self and then it is going to turn you into a different person or individual whom the people who are close to you would identify as to something different that you are going through and the changes are pretty evident.


It is really important that the condition of depression is being diagnosed as early as possible because then it would be possible to treat it. If this condition is not detected early, then an individual will display a very different behavior with time and this is going to affect their mental and emotional health in a very disastrous way.


It is really important that this condition is recognized as soon as possible because it can turn the happy and healthier life into a living hell, which is not only going to have a pretty strong impact on the life of the individual who is going through but also will damage the mental and emotional being of the entire family.


by depressiondoctor on April 7th, 2006

Depression & You

Depression is a psychiatric disorder in which the individual can go through any of the symptoms such as they can lose the ability to concentrate, loss of sleep, loss of appetite, lack of interest in the activities that one used to have, extreme degree of sadness, feelings of guilt, feelings of helplessness and feelings of hopelessness and even to the extreme degrees one thinks about death.

Now you need to know as to what are things that you are going through from as mentioned above. It is really important that you need to identify and differentiate your different feelings so that you are able to know as to exactly the nature of your feelings. If you are able to identify any one of the feelings inside you, then you can say that you are going through a bout of depression.
You need to remember and know as to how many times you have been through these feelings so as to understand as to how long you have been going through the bouts of depression and you and neither the people around you noticed the changes in your feelings.

Do you see as to how the depression is affecting your life and how it is progressing to deteriorate the balance in your life and uprooting you slowly and gradually. You need to take this very seriously and know the fact that you need to get out of this situation you are in.

Just remember that you are the captain of your ship and you are the one who is going to steer yourself out of this situation rather than any other person. You need to grip yourself and need to know that you need to stop the things that are growing inside of you and see as to how you would be able to come out of it.

This is a war between you and your state that is trying to overcome you and you can beat this thing that is creeping up on you. It is really very important that you feel your heart and do not let yourself drown in the feelings that you are in because this is the time that you realize that you need to take off the cloak of the feelings that you are getting into.

I believe that you can come out of it and can win over the feelings that are trying to cover you all.

by depressiondoctor on April 7th, 2006

Kamarani